Osborne signal path starts with a ¼ cable from his guitar into his TC Polytune tuner. From there it hits his Dunlop Crybaby classic w/Fasel Inductor. Next it hits a Road Rage true-bypass loop switcher that routes that signal like this: Electro-Harmonix Micro Q-Tron,  Boss OC-2 Octave, Boss/DS-1 Distortion, Walrus Audio Voyager, Xotic AC Plus, Mojo Hand Fx Nebula IV, Hughes & Kettner Rotosphere MK II, Mojo Hand Fx Recoil, Boss DD-3 Digital Delay, Mojo Hand Fx Colossus Fuzz, Lovepedal Babyface Tremolo, and Analog Man Sun Face Fuzz.

Two Voodoo Labs Pedal Power 2 Plus units provide the juice. Everything rests on a Pedaltrain PT-Pro board. He uses Planet Waves Solderless Cables make all pedalboard connections and a Planet Waves Classic Series Instrument cable runs from the guitar to the pedalboard and from the Radial JX-2 to the amps and to and from a Radial Headbone VT Amp Head switcher that lives on top of the Marshall.